Sex-Specific Effects of Ancestral Stress on Brain Health and Disease Across the Lifespan

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dc.contributor.authorAmbeskovic, Mirela
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMetz, Gerlinde A. S.
dc.date.accessioned2019-06-19T18:03:05Z
dc.date.available2019-06-19T18:03:05Z
dc.date.issued2019
dc.degree.levelPh.Den_US
dc.description.abstractEarly life stress alters fetal brain development with lifetime consequences on individuals exposed and future generations. This thesis investigated the effects of ancestral stress on behaviour, brain aging, and disease incidence of the F1-F4 generation offspring. Two types of ancestral stress offspring were examined: transgenerational stress, where only great-great grandma was stressed and mutigenerational stress where four consecutive F0-F3 generations were stressed during pregnancy. Here were report three main findings: 1) ancestral stress induced sex-specific anxiety-like behaviour and brain plasticity through altered epigenetic regulation; 2) the effects of ancestral stress persisted across the lifespan, altered physical and mental health and increased risk of disease; and 3) social isolation stress altered stress and immune systems and contributed to sex-specific cognitive impairments. These findings contribute to the overall understanding of the perinatal origins of healthy brain aging and disease, and address the urgent need of recommendations to support healthy aging worldwide.en_US
dc.description.sponsorshipNatural Sciences and Engineering Research Council (NSERC) PGS Canadian Institutes of Health Research (CIHR)en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/5410
dc.language.isoen_USen_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquest.subjectPsychobiology [0349]en_US
dc.proquest.subjectBehavioral psychology [0384]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectStressen_US
dc.subjectBehviouren_US
dc.subjectBrain agingen_US
dc.subjectDiseaseen_US
dc.subjectEpigeneticsen_US
dc.subjectSex-specific effectsen_US
dc.titleSex-Specific Effects of Ancestral Stress on Brain Health and Disease Across the Lifespanen_US
dc.typeThesisen_US
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