Neural ensemble interactions underlying memory consolidation

Simple item page
dc.contributor.authorSchwindel, C. Daniela
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2015-05-12T19:55:55Z
dc.date.available2015-05-12T19:55:55Z
dc.date.issued2014
dc.degree.levelPh.Den_US
dc.description.abstractEpisodic memory formation and spatial navigation are core functions of the hippocampus. Embedded in a path integration based navigational system, the hippocampus generates orthogonal codes for different environments. To separate events within the same spatial map, the magnitude of individual place cell firing is modulated by external sensory information. The rate differences are also expressed to separate different running directions within an environment. Previous work suggested that the maps can be perturbed by external cues, but that the rate perturbations are not associatively stored. The present result shows that the rate code is reinstated offline and thus likely associatively stored, which fits well with the theory that describes the hippocampus as generating an index code for episodic memories to assist in retrieval of distributed information stored in the cortex. Lastly, this thesis addresses the methodological challenges of current electrophysiological techniques in detecting excitatory local connectivity on the example of the prefrontal cortex.en_US
dc.description.sponsorshipAI-HS scholarship to CDS and Polaris Award to BLMen_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/3684
dc.language.isoen_CAen_US
dc.proquest.subjectNeurosciences 0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjecthippocampusen_US
dc.subjectraten_US
dc.subjectepisodic memoryen_US
dc.subjectelectrophysiologyen_US
dc.subjectplace cellsen_US
dc.titleNeural ensemble interactions underlying memory consolidationen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
SCHWINDEL_DANIELA_PHD_2014.pdf
Size:
20.89 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses