Anxiety behaviour and inflammatory markers in c57/bl6j mice are enhanced after a chronic dose of DSS colitis during contextual fear conditioning

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dc.contributor.authorBeekman, Kaylen A
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorGruber, Aaron J.
dc.date.accessioned2024-05-30T16:09:46Z
dc.date.available2024-05-30T16:09:46Z
dc.date.issued2024
dc.degree.levelMasters
dc.description.abstractThis thesis describes how induced gut inflammation induces brain inflammation via the brain-gut axis. It further shows that mice with elevated gut inflammation display post-shock behavioural correlates of anxiety for longer duration than mice that do not have gut inflammation. The gut-inflamed mice also show a reduced ability to recover from fearful experiences and higher relative quantities of inflammatory markers in the nucleus accumbens. Mice receiving both gut inflammation and psilocybin show reduced anxiety behaviour and lower relative quantities of inflammatory markers in the nucleus accumbens. This thesis demonstrates that induced gut inflammation drives increased inflammation in the nucleus accumbens and results in increased measures of anxiety in conditioned and unconditioned behavioural tasks. Some outcomes were ameliorated by the addition of a single dose of psilocybin. Overall, these data improve understanding of potential mechanisms by which anxiety may be produced and treated. Research was completed under protocol number 2018.
dc.description.sponsorshipNSERC
dc.embargoNo
dc.identifier.urihttps://hdl.handle.net/10133/6758
dc.language.isoen
dc.proquest.subject0347
dc.proquest.subject0317
dc.proquestyesYes
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectanxiety behaviour
dc.subjectinflammatory markers
dc.subjectcontextual fear conditioning
dc.subjectgut inflammation
dc.subjectbrain inflammation
dc.subjectbrain-gut axis
dc.subjectc57/bl6j mice
dc.subject.lcshInflammatory bowel diseases--Animal models
dc.subject.lcshInflammation--Animal models
dc.subject.lcshInflammation--Research
dc.subject.lcshEncephalitis--Animal models
dc.subject.lcshNucleus accumbens--Research
dc.subject.lcshAnxiety--Research
dc.subject.lcshGastointestinal system--Innervation--Research
dc.subject.lcshCentral nervous system--Research
dc.subject.lcshDissertations, Academic
dc.subject.lcshMice as laboratory animals
dc.titleAnxiety behaviour and inflammatory markers in c57/bl6j mice are enhanced after a chronic dose of DSS colitis during contextual fear conditioning
dc.typeThesis
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