Effect of copper nanoparticles on rainbow trout olfaction and recovery

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dc.contributor.authorRazmara, Parastoo
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorPyle, Gregory
dc.date.accessioned2021-05-28T20:39:26Z
dc.date.available2021-05-28T20:39:26Z
dc.date.issued2021
dc.degree.levelPh.Den_US
dc.description.abstractFish depend on olfaction for reproduction and survival. Here, using molecular to behavioural endpoints, we compared the effect of two neurotoxic contaminants, Cu ions (Cu2+) and copper nanoparticles (CuNPs) on rainbow trout olfaction. Exposure to equitoxic concentrations of Cu2+ and CuNPs resulted in distinct toxicity patterns over time in rainbow trout olfactory mucosa. During continuous exposure to Cu2+, fish olfactory function was partially recovered. However, the olfactory function of CuNP-exposed fish showed a steady decline over time. Gene-transcript profiles of Cu2+-exposed olfactory mucosa showed neural repair mechanisms were upregulated to recover the olfactory dysfunction. In the CuNP treatment, dysregulation of transcripts that regulate function and reestablishment of damaged olfactory mucosa represented key mechanisms of CuNP-induced olfactory toxicity. Moreover, our findings revealed the CuNP-induced olfactory dysfunction was irreversible after the 7-day recovery period. Collectively, CuNPs and Cu2+ exert their effects via separate mechanisms in rainbow trout olfactory mucosa.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5897
dc.language.isoen_USen_US
dc.proquest.subject0383en_US
dc.proquest.subject0317en_US
dc.proquest.subject0306en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciencesen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjecttoxicologyen_US
dc.subjectcopper nanoparticlesen_US
dc.subjectrainbow trouten_US
dc.subjectolfactory sensory neuronsen_US
dc.subjectCopper -- Toxicologyen_US
dc.subjectRainbow trout -- Sense organs -- Effect of heavy metals onen_US
dc.subjectNanoparticles -- Toxicologyen_US
dc.subjectNeurotoxic agentsen_US
dc.subjectSmellen_US
dc.subjectOlfactory receptorsen_US
dc.subjectDissertations, Academicen_US
dc.titleEffect of copper nanoparticles on rainbow trout olfaction and recoveryen_US
dc.typeThesisen_US
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