The effect of development on spatial pattern separation in the hippocampus as quantified by the Homer1a immediate-early gene

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dc.contributor.authorXie, Jeanne Yan
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2014-05-05T20:55:28Z
dc.date.available2014-05-05T20:55:28Z
dc.date.issued2013
dc.degree.levelMastersen_US
dc.descriptionix, 51 leaves : ill. ; 29 cmen_US
dc.description.abstractThis study sought to determine whether the DG, CA3, and CA1 regions contain uniformly excitable populations and test the hypothesis that rapid addition of new, more excitable, granule cells in prepubescence results in a low activation probability (P1) in the DG. The immediate-early gene Homer1a was used as a neural activity marker to quantify activation in juvenile (P28) and adult (~5 mo) rats during track running. The main finding was that P1 in juveniles was substantially lower not only the DG, but also CA3 and CA1. The P1 for a DG granule cell was close to 0 in juveniles, versus 0.58 in adults. The low P1 in juveniles indicates that sparse, but non-overlapping, subpopulations participate in encoding events. Since sparse, orthogonal coding enhances a network’s ability to decorrelate input patterns (Marr, 1971; McNaughton & Morris, 1987), the findings suggest that juveniles likely possess greatly enhanced pattern separation ability.en_US
dc.identifier.urihttps://hdl.handle.net/10133/3414
dc.language.isoen_CAen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2013en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectHippocampus (Brain) -- Researchen_US
dc.subjectDentate gyrus -- Researchen_US
dc.subjectLearning -- Physiological aspects -- Researchen_US
dc.subjectMemory -- Physiological aspects -- Researchen_US
dc.subjectSpace perception -- Researchen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectNeuronsen_US
dc.subjectDissertations, Academicen_US
dc.titleThe effect of development on spatial pattern separation in the hippocampus as quantified by the Homer1a immediate-early geneen_US
dc.typeThesisen_US
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