The molecular mechanisms underlying epigenetics of the stress response in the cerebellum in a rat model

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dc.contributor.authorBabenko, Olena M.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Igor
dc.contributor.supervisorMetz, Gerlinde A. S.
dc.date.accessioned2012-02-09T23:32:57Z
dc.date.available2012-02-09T23:32:57Z
dc.date.issued2010
dc.degree.levelMasters
dc.descriptionxii, 109 leaves. : ill. ; 29 cmen_US
dc.description.abstractPrevious findings showed that mild chronic restraint stress causes motor impairments in rats. These behavioural impairments might be related to molecular changes in brain areas that regulate motor functions, such as the cerebellum. Little is known about the role of the cerebellum in stress-induced behavioural alteration. We hypothesized that alteration in animal behaviour after chronic restraint stress is due to brain-specific changes in miRNA and proteins encoding gene expression. Our results revealed that expression of three miRNAs and 39 mRNAs was changed significantly after two weeks of stress. Furthermore, we verified one putative target for one of the changed miRNAs and expression of four randomly selected genes. Changes in gene expression disappeared after two weeks of recovery from stress. These findings provide a novel insight into stress-related mechanisms of gene expression underlying altered behavioural performance. The observations bear implications for the prevention and treatment of stress-related disorders and disease.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2604
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010en_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectStress (Physiology) -- Researchen_US
dc.subjectCerebellum -- Effect of stress on -- Researchen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectRats -- Effect of stress onen_US
dc.subjectEpigenetics -- Researchen_US
dc.subjectDissertations, Academicen_US
dc.titleThe molecular mechanisms underlying epigenetics of the stress response in the cerebellum in a rat modelen_US
dc.typeThesisen_US
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