Reactivation of rate remapping in CA3

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dc.contributor.authorSchwindel, C. Daniela
dc.contributor.authorNavratilova, Zaneta
dc.contributor.authorAli, Karim
dc.contributor.authorTatsuno, Masami
dc.contributor.authorMcNaughton, Bruce L.
dc.date.accessioned2019-04-23T19:33:40Z
dc.date.available2019-04-23T19:33:40Z
dc.date.issued2016
dc.descriptionSherpa Romeo yellow journal. Open access article. Creative Commons Attribution 4.0 International License (CC BY 4.0) appliesen_US
dc.description.abstractThe hippocampus is thought to contribute to episodic memory by creating, storing, and reactivating patterns that are unique to each experience, including different experiences that happen at the same location. Hippocampus can combine spatial and contextual/episodic information using a dual coding scheme known as “global” and “rate” remapping. Global remapping selects which set of neurons can activate at a given location. Rate remapping readjusts the firing rates of this set depending on current experience, thus expressing experience-unique patterns at each location. But can the experience-unique component be retrieved spontaneously? Whereas reactivation of recent, spatially selective patterns in hippocampus is well established, it is never perfect, raising the issue of whether the experiential component might be absent. This question is key to the hypothesis that hippocampus can assist memory consolidation by reactivating and broadcasting experience-specific “index codes” to neocortex. In CA3, global remapping exhibits attractor-like dynamics, whereas rate remapping apparently does not, leading to the hypothesis that only the former can be retrieved associatively and casting doubt on the general consolidation hypothesis. Therefore, we studied whether the rate component is reactivated spontaneously during sleep. We conducted neural ensemble recordings from CA3 while rats ran on a circular track in different directions (in different sessions) and while they slept. It was shown previously that the two directions of running result in strong rate remapping. During sleep, the most recent rate distribution was reactivated preferentially. Therefore, CA3 can retrieve patterns spontaneously that are unique to both the location and the content of recent experience.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationSchwindel, C. D., Navratilova, Z., Ali, K., Tatsuno, M., & McNaughton, B. L. (2016). Reactivation of rate remapping in CA3. Journal of Neuroscience, 36(36), 9342-9350. DOI:10.1523/JNEUROSCI.1678-15.2016en_US
dc.identifier.urihttps://hdl.handle.net/10133/5333
dc.language.isoen_USen_US
dc.publisherSociety for Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.institutionUniversity of Californiaen_US
dc.publisher.institutionNeuroelectronic Research Flandersen_US
dc.publisher.urlhttps://doi.org/10.1523/JNEUROSCI.1678-15.2016
dc.subjectCA3en_US
dc.subjectEpisodic memoryen_US
dc.subjectHippocampusen_US
dc.subjectMemory reactivationen_US
dc.subjectRate remappingen_US
dc.subjectGlobal remapping
dc.subject.lcshHippocampus (Brain)
dc.subject.lcshMemory--Research
dc.subject.lcshRats as laboratory animals
dc.titleReactivation of rate remapping in CA3en_US
dc.typeArticleen_US
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