Epigenetic regulation of stroke recovery : changes in DNA methylation and micro-RNA regulation following stroke and EGF/EPO neurogenesis therapy

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dc.contributor.authorLowings, Michael D.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2011-12-07T23:14:25Z
dc.date.available2011-12-07T23:14:25Z
dc.date.issued2010
dc.degree.levelMasters
dc.descriptionx, [99] leaves : ill. (some col.) ; 29 cmen_US
dc.description.abstractStroke is one of the most common, and damaging, neurological afflictions. Stroke causes widespread and variable chronic effects, due to the limited regenerative ability of the adult brain. Altered gene expression induces neuronal changes necessary for plasticity-dependent recovery, effects which can be enhanced by growth hormone-based pharmaceuticals. These processes are driven by alterations in the informational capacity of the genome – changes driven by epigenetic regulators. Following experimental strokes, and treatment with EGF and EPO, this study shows that two epigenetic regulatory mechanisms, DNA methylation and microRNA regulation, are significantly altered, both in treated and untreated animals. Specifically, treatment induces a net global suppression of miRNA activity, which appears to modify the physical behaviour of neurons in domains ranging from plasticity and memory formation, growth and replication, and potentially even to neurological disease signalling. The confirmation of epigenetic alterations following a stroke indicates a future role for epigenetic neuro-pharmacology in stroke management.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2570
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010en_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectCerebrovascular disease -- Researchen_US
dc.subjectNeuroplasticity -- Researchen_US
dc.subjectNeuropharmacology -- Researchen_US
dc.subjectEpigenesis -- Researchen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectDissertations, Academicen_US
dc.titleEpigenetic regulation of stroke recovery : changes in DNA methylation and micro-RNA regulation following stroke and EGF/EPO neurogenesis therapyen_US
dc.typeThesisen_US
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