Reduced peri-infarct dysfunction with pre-stroke exercise : molecular and physiological correlates

dc.contributor.authorCooper, Natalie R.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKleim, Jeffrey
dc.date.accessioned2007-05-12T20:34:28Z
dc.date.available2007-05-12T20:34:28Z
dc.date.issued2003
dc.degree.levelMasters
dc.description140 leaves : ill. (some col.) ; 29 cm.en
dc.description.abstractThe effects of pre-stroke exercise and levesl of brain-derived neurotrophic factor (BDNF) on behavioural and functional recovery were examined following focal cortical ischemic infarct. Intracortical microstimulation (ICMS) was used to derive topographical maps of forelimb representations within the motor cortex and ischemia was induced via bipolar coagulation of surface vasculature. One month of excerise prior to ischemia significantly increased the amount of peri-infarct movement represnetations and initiates vascular changes within motor cortex. Further, this exercise-induced preservation of peri-infarct movement representations is associated with behavioural recovery and is dependent on BDNF levels in the motor cortex. These results provide further support for the idea that endurance exercise prior to stroke may enhance functional and behavioural recovery.en
dc.identifier.urihttps://hdl.handle.net/10133/215
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003en
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectCerebrovascular disease -- Researchen
dc.subjectCerebrovascular disease -- Patients -- Rehabilitationen
dc.subjectExercise -- Health aspectsen
dc.titleReduced peri-infarct dysfunction with pre-stroke exercise : molecular and physiological correlatesen
dc.typeThesisen
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