Radiation-induced epigenome deregulation in the male germline

Simple item page
dc.contributor.authorTamminga, Jan
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2009-07-08T20:49:32Z
dc.date.available2009-07-08T20:49:32Z
dc.date.issued2008
dc.degree.levelMasters
dc.descriptionxii, 121 leaves : ill. ; 29 cm.en
dc.description.abstractApproximately 45% of men will develop cancer during their lifetime; some of which will be of reproductive age (Canadian Cancer Society, 2008). Current advances in treatment regimens such as radiotherapy have significantly lowered cancer-related mortality rates; however, one major quality-of-life issue in cancer survivors is the ability to produce healthy offspring. Exposure to ionizing radiation (IR) leads to genomic instability in the germline, and further to transgeneration genome instability in unexposed offspring of preconceptionally exposed parents. The results presented in this thesis define, in part, the molecular consequences of direct and indirect irradiation for the male germline. Direct exposure results in a significant accumulation of DNA damage, altered levels of global DNA methylation and microRNAome dysregulation of testis tissue. Localized cranial irradiation results in a significant accumulation of unrepaired DNA lesions and loss of global DNA methylation in the rodent (rat) germline. Biological consequences of the changes observed are discussed.en
dc.identifier.urihttps://hdl.handle.net/10133/746
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008en
dc.publisher.departmentBiological Sciencesen
dc.publisher.facultyArts and Scienceen
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectRadiation carcinogenesis -- Animal modelsen
dc.subjectRadiation carcinogenesisen
dc.subjectDNA -- Effect of radiation onen
dc.subjectCancer -- Radiography -- Complications -- Researchen
dc.subjectGerm cells -- Effect of radiation onen
dc.titleRadiation-induced epigenome deregulation in the male germlineen
dc.typeThesisen
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
TAMMINGA_JAN_MSC_2008.pdf
Size:
1.61 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.88 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses