Mapping behaviourally induced immediate-early gene expression along the septotemporal axis of CA1

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dc.contributor.authorDube, Sutherland Theresa Ann
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2017-03-02T22:05:16Z
dc.date.available2017-03-02T22:05:16Z
dc.date.issued2016
dc.degree.levelMastersen_US
dc.description.abstractThe longitudinal (or septotemporal) axis of the rodent hippocampus is generally described as being functionally segregated. However, the division between septal and temporal areas is not clearly delineated, and current anatomic, genetic, and physiological data propose varying gradients and domains that in large part do not coincide. In an attempt to clarify these issues, we mapped the behaviourally induced activity of neurons throughout the longitudinal axis of CA1 using immediate early genes (IEGs), which enable large-scale analysis of neuronal activity at the cellular level with a high degree of spatial resolution. Interestingly, the IEG data were not consistent with any of the proposed anatomical schemas or with the available single neuron recording data. The data suggest an alternative classification of hippocampal modules, with a functional domain in septal CA1 and a functional gradient through intermediate and temporal CA1. We suggest delineation between these two subdivisions of CA1 could correspond to amygdalar input to CA1. Further experiments could provide information on whether this input provides a basis for functional segregation at the level of neural activity dependent IEG expression.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/4789
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquest.subject0307en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectblobsen_US
dc.subjectCA1en_US
dc.subjecthippocampal longitudinal axisen_US
dc.subjectHomer1aen_US
dc.subjectimmediate-early genesen_US
dc.subjectintranuclear transcription focien_US
dc.titleMapping behaviourally induced immediate-early gene expression along the septotemporal axis of CA1en_US
dc.typeThesisen_US
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