The effects of early developmental exposure to 3,3'4,4'5-pentachlorobiphenyl (PCB 126) on developing mink (Neovison vison) and domestic chick (Gallus domesticus) brains

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dc.contributor.authorBurger, Danielle K.
dc.contributor.supervisorIwaniuk, Andrew N.
dc.date.accessioned2015-01-29T22:06:43Z
dc.date.available2015-01-29T22:06:43Z
dc.date.issued2014
dc.degree.levelMastersen_US
dc.degree.levelMasters
dc.description.abstractPolychlorinated biphenyls (PCBs) are environmental toxicants that bioaccumulate in the body. PCB 126 is the most toxic PCB congener due to its ability to mimic the effects of dioxins. Here, I examined the effects of early developmental PCB 126 exposure in two animal models. In the first experiment, American mink kits were exposed prenatally and postnatally to PCB 126. The effects of early exposure were examined in the hippocampus, neocortex and corpus callosum. PCB 126 exposure had no effect on the hippocampus, but decreased volume of both the neocortex and corpus callosum. In the second experiment, chick eggs were injected with PCB 126 and the effects of embryonic exposure in the brain were examined in the telencephalon and hippocampus. Overall, I found no effects of PCB 126 on the chick brain. Taken together, my two experiments suggest PCB 126 has effects on the brain, but species sensitivity may differ.en_US
dc.description.sponsorshipNSERC and AITF funding to Dr. Iwaniuken_US
dc.identifier.urihttps://hdl.handle.net/10133/3632
dc.language.isoen_CAen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectNeuroscienceen_US
dc.subjectcorpus callosumen_US
dc.subjectearly developmental exposureen_US
dc.subjectenvironmental toxinsen_US
dc.subjecthippocampusen_US
dc.subjectneocortexen_US
dc.subjecttelencephalonen_US
dc.titleThe effects of early developmental exposure to 3,3'4,4'5-pentachlorobiphenyl (PCB 126) on developing mink (Neovison vison) and domestic chick (Gallus domesticus) brainsen_US
dc.typeThesisen_US
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