Effects of behavioral therapies and pharmacological intervention in brain damage

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dc.contributor.authorWitt-Lajeunesse, Alane
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKolb, Bryan
dc.date.accessioned2007-04-25T19:37:31Z
dc.date.available2007-04-25T19:37:31Z
dc.date.issued2001
dc.degree.levelMasters
dc.descriptionxv, 127 leaves : ill. ; 28 cm.en
dc.description.abstractMaximizing recovery of function after brain injury is the goal for many neuroscientists and rehabilitation medicine professional alike. To further elucidate the neural mechanisms underlying compensatory changes in brain injury and to determine the possibility of enhancing these changes, three experiments are described. Experiment 1 looks at the effects of structured (skilled reaching) versus functional (enriched environment) training with and without FGF-2, a pharmacological intervention, as treatment paradigms for rehabilitation-induced recovery of function in cortical lesion adult rats. Experiment 2 examines the treatment effects of tactile stimulation to enhance motor abilities in postnatal day 4 rat pups sustaining cortical damage. Finally, experiment 3 explores changes in the cortical motor representation after cortical damage. Results indicate a marked improvement on behavioral testing combing FGF-2 and functional training. Tactile stimulation significantly enhances recovery of motor functions. Post-lesion cortical mapping reveals changes in the motor representation utilizing the adjacent posterior parietal cortex.en
dc.identifier.urihttps://hdl.handle.net/10133/149
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2001en
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectBrain damageen
dc.subjectBrain damage -- Patients -- Rehabilitationen
dc.subjectDissertations, Academicen
dc.titleEffects of behavioral therapies and pharmacological intervention in brain damageen
dc.typeThesisen
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