Pharmacokinetics of Doxorubicin in cancer chemotherapy

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dc.contributor.authorFawehinmi, Festus
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorVos, Ken
dc.date.accessioned2020-03-23T15:31:31Z
dc.date.available2020-03-23T15:31:31Z
dc.date.issued2020
dc.degree.levelMastersen_US
dc.description.abstractThe pharmacokinetics (PK) of doxorubicin (DOX) is characterized by a large degree of inter-individual variation, which translates to unpredictability in the drug toxicity and response profiles from one individual to the next. In this work, we introduce a saturable model of DOX PK with fractal exponents using a population PK approach. The initial one-compartment model was expanded to a two-molecule model of DOX and encapsulated DOX, and a four-molecule, three-compartment model of DOX and its toxic metabolite doxorubicinol (DOL). Using this approach, the kinetic parameters of the molecules were developed by minimizing the weighted percentage variance of individual models. Our model provides interesting insights when testing the effects of some covariates on the PK of the molecules. We notice that factors such as patients' gender, race, body weight and liver impairment influence the elimination PK of DOX and DOL.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5700
dc.language.isoen_USen_US
dc.proquest.subjectOncology [0992]en_US
dc.proquest.subjectPharmaceutical sciences [0572]en_US
dc.proquest.subjectToxicology [0383]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Physics and Astronomyen_US
dc.publisher.departmentPhysics and Astronomyen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectCancer -- Chemotherapyen_US
dc.subjectChemotherapyen_US
dc.subjectDoxorubicinen_US
dc.subjectDrugs -- Toxicologyen_US
dc.subjectPharmacokineticsen_US
dc.subjectPharmacologyen_US
dc.titlePharmacokinetics of Doxorubicin in cancer chemotherapyen_US
dc.typeThesisen_US
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