Environmental intervention as a therapy for adverse programming by ancestral stress

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dc.contributor.authorMcCreary, J. Keiko
dc.contributor.authorErickson, Zachary T.
dc.contributor.authorHao, XongXin
dc.contributor.authorIlnytskyy, Yaroslav
dc.contributor.authorKovalchuk, Igor
dc.contributor.authorMetz, Gerlinde A. S.
dc.date.accessioned2020-02-21T20:05:05Z
dc.date.available2020-02-21T20:05:05Z
dc.date.issued2016
dc.descriptionSherpa Romeo green journal. Open access article. Creative Commons Attribution 4.0 International License (CC BY 4.0) appliesen_US
dc.description.abstractAncestral stress can program stress sensitivity and health trajectories across multiple generations. While ancestral stress is uncontrollable to the filial generations, it is critical to identify therapies that overcome transgenerational programming. Here we report that prenatal stress in rats generates a transgenerationally heritable endocrine and epigenetic footprint and elevated stress sensitivity which can be alleviated by beneficial experiences in later life. Ancestral stress led to downregulated glucocorticoid receptor and prefrontal cortex neuronal densities along with precocious development of anxiety-like behaviours. Environmental enrichment (EE) during adolescence mitigated endocrine and neuronal markers of stress and improved miR-182 expression linked to brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) regulation in stressed lineages. Thus, EE may serve as a powerful intervention for adverse transgenerational programming through microRNA-mediated regulation of BDNF and NT-3 pathways. The identification of microRNAs that mediate the actions of EE highlights new therapeutic strategies for mental health conditions and psychiatric disease.
dc.description.peer-reviewYesen_US
dc.identifier.citationMcCreary, J. K., Erickson, Z. T., Hao, Y., Ilnytskyy, Y., Kovalchuk, I., & Metz, G. A. S. (2016). Environmental intervention as a therapy for adverse programming by ancestral stress. Scientific Reports, 6, 37814. DOI: 10.1038/srep37814en_US
dc.identifier.urihttps://hdl.handle.net/10133/5694
dc.language.isoen_USen_US
dc.publisherNature Researchen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.urlhttps://doi.org/10.1038/srep37814en_US
dc.subjectEpigenetics and behaviouren_US
dc.subjectStress and resilienceen_US
dc.subjectAncestral stress
dc.subjectTransgenerational programming
dc.subjectEnvironmental enrichment
dc.subjectmicroRNAs
dc.subjectPrenatal stress
dc.subject.lcshEnvironmental enrichment (Animal culture)
dc.subject.lcshRats--Environmental enrichment
dc.titleEnvironmental intervention as a therapy for adverse programming by ancestral stressen_US
dc.typeArticleen_US
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