Can stress modulate the severity of convulsions and subsequent behavioural outcome?

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dc.contributor.authorEjaredar, Maede
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSaucier, Deborah
dc.date.accessioned2015-10-29T02:12:12Z
dc.date.available2015-10-29T02:12:12Z
dc.date.issued2008
dc.degree.levelMastersen_US
dc.description.abstractStatus epilepticus is prolonged seizure activity lasting for more than 30 minutes that result in a series of morphological alterations in the brain as well as some changes in the behaviour. Experiment 1 examined the relation between status epilepticus, spontaneous seizures, hippocampal volume and the behaviour of rats that had experienced status epilepticus. Experiment 2 examined the relation that stress and status epilepticus had on hippocampal volume, spontaneous convulsions and a subset of the behaviours from Experiment 1. The results of this thesis confirm that status epilepticus is associated with hippocampal volume loss. Status epilepticus and/or reductions in hippocampal volume may result in behavioural impairments, especially in spatial memory. Unlike some of the other studies, stress did not change the hippocampal volume nor did it interact with status to produce further change. Further investigations are required to confirm whether stress has a compounding effect on status epilepticus and subsequent seizure disorders.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/3772
dc.language.isoen_CAen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Department of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjecthippocampusen_US
dc.subjectspontaneous seizuresen_US
dc.subjectstatus epilepticusen_US
dc.subjectstressen_US
dc.titleCan stress modulate the severity of convulsions and subsequent behavioural outcome?en_US
dc.typeThesisen_US
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