In Vivo Imaging of Experience-Dependent Plasticity in the Retrosplenial Cortex Following Unilateral Hippocampal Lesions

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dc.contributor.authorTorry, Megan E.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2019-06-19T18:44:05Z
dc.date.available2019-06-19T18:44:05Z
dc.date.issued2019
dc.degree.levelMastersen_US
dc.description.abstractMechanisms of learning and memory influence brain connectivity. Hippocampal outflow targets the ipsilateral retrosplenial cortex (RSC) and thus influences plasticity in the neocortex. Evidence from fixed tissue suggests that hippocampal lesions prevent the increase in dendritic spines due to an enrichment environment; however, may prevent observation of a larger effect on synaptic turnover across time. Longitudinal two-photon microscopy was used to compare specific ipsilateral and contralateral RSC locations in vivo, before and after enrichment. Consolidation theory predicts that in the absence of one hippocampus the ipsilateral RSC will undergo asymmetry in plasticity following enrichment exposure. In both hemispheres, synaptic turnover persists during home-cage housing with a slight transient increase following transfer to enrichment. There was greater axon growth and a lasting ~7% increase in spine density in the RSC ipsilateral to the lesion. Irregularities in transgenic mouse genetics, and particulars regarding the functionality between pre and post-synaptic elements remain enigmatic.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/5412
dc.language.isoen_USen_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquest.subjectBehavioral sciences [0602]en_US
dc.proquest.subjectCognitive psychology [0633]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectenvironmental enrichmenten_US
dc.subjectAxon boutonsen_US
dc.subjectDendritic spinesen_US
dc.subjectIn vivo imagingen_US
dc.subjectTwo photon microscopyen_US
dc.titleIn Vivo Imaging of Experience-Dependent Plasticity in the Retrosplenial Cortex Following Unilateral Hippocampal Lesionsen_US
dc.typeThesisen_US
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