Neural correlates of parallel and distributed engrams

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dc.contributor.authorChang, HaoRan
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcNaughton, Bruce L.
dc.contributor.supervisorMohajerani, Majid H.
dc.date.accessioned2024-02-01T20:27:00Z
dc.date.available2024-02-01T20:27:00Z
dc.date.issued2023
dc.degree.levelPh.D
dc.description.abstractFrom the waking hours into the depths of sleep, the hippocampus and the neocortex engage in an enigmatic dialogue on that which occurs, that which had occurred and that which could occur eventually. Together, this information weaves the memories of our past and the knowledge of our world. Yet, if one attempts to eavesdrop on this conversation, they would be perplexed to discover that the details that would give rise to such sophisticated structures could mostly be diluted into the mapping of space. What invisible bonds may tie space and memory in the brain, this present thesis offers no answers for. What it does offer, instead, are more enigmas to be fancied over and more confusions to be resolved: (1) The neural representation of space is found across multiple regions of the dorsal cortex and necessitates an intact hippocampus to form; (2) During offline periods, the retrosplenial cortex spontaneously reinstates patterns of activity specifically related to the locations of spatial landmarks; (3) The secondary motor cortex, in contrast, reinstates a conjunction of spatial and non-spatial information, in the forms of recent trajectories undertaken in an environment and the locations of visuo-tactile landmarks, respectively. Together, these results elaborate a spatial code that is heavily redundant and dispersed, with a link to mnemonic processing — a neural correlate of parallel and distributed engrams.
dc.description.sponsorshipNSERC Canada Graduate Scholarships — Doctoral (CGS D)
dc.identifier.urihttps://hdl.handle.net/10133/6679
dc.language.isoen
dc.proquest.subject0317
dc.proquest.subject0633
dc.proquestyesYes
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectlearning & memory
dc.subjectconsolidation
dc.subjecthippocampo-neocortical dialogue
dc.subjectreactivation
dc.subjectplace cells
dc.subjecttwo-photon calcium imaging
dc.subjectspatial/non-spatial representations
dc.subjectvirtual reality
dc.subjectspatial landmarks
dc.subjectpattern completion
dc.subjectengrams
dc.subjectspatial memory
dc.subjectnavigation
dc.subjectsharp-wave ripples
dc.subjectretrospenial cortex
dc.subjecthippocampal lesion
dc.subjectsecondary motor cortex
dc.subject.lcshLearning--Physiological aspects--Research
dc.subject.lcshMemory--Physiological aspects--Research
dc.subject.lcshMemory consolidation--Research
dc.subject.lcshHippocampus (Brain)--Research
dc.subject.lcshNeocortex--Research
dc.subject.lcshSpace perception--Research
dc.subject.lcshCognitive neuroscience
dc.subject.lcshMental representation--Research
dc.subject.lcshNervous system--Imaging
dc.subject.lcshSpatial behavior--Research
dc.subject.lcshSpatial ability--Research
dc.subject.lcshDissertations, Academic
dc.titleNeural correlates of parallel and distributed engrams
dc.typeThesis
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