Behavioural and neurophysiological expression of visual categorization in the mouse medial prefrontal cortex

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dc.contributor.authorPais, Rui
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2021-07-19T15:52:21Z
dc.date.available2021-07-19T15:52:21Z
dc.date.issued2021
dc.degree.levelPh.Den_US
dc.description.abstractCategorization is a process that allows organisms to classify and respond to individual elements of any given experience based on their shared similarities, and to generalize their behavioural output to novel stimuli that share the same features. In this set of experiments we explored the underlying neural dynamics of visual categorization in mice by developing a virtual reality task using an automated touchscreen operant conditioning box. By gradually incrementing the number of exemplars available in a pairwise object recognition task, mice learned to discriminate between virtual objects that belong to 2 main categories. We also tried to determine if the neural activity in the mouse prefrontal cortex, a region which has been associated with category representations in primates, reflected the acquisition of this new information. In order to do this we used in-vivo 2-photon calcium imaging to record the neural activity of a cohort of mice at different time points.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5960
dc.language.isoen_USen_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquest.subjectBiochemistry [0487]en_US
dc.proquest.subjectBiology [0306]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectDissertations, Academicen_US
dc.subjectAnimal behavioren_US
dc.subjectCategorization (Psychology)en_US
dc.subjectNeuropsychologyen_US
dc.subjectPrefrontal cortexen_US
dc.subjectVirtual realityen_US
dc.subjectVisual cognitionen_US
dc.titleBehavioural and neurophysiological expression of visual categorization in the mouse medial prefrontal cortexen_US
dc.typeThesisen_US
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