The aging hippocampus : a multilevel analysis in the rat

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dc.contributor.authorDriscoll, Ira
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.en
dc.date.accessioned2007-03-23T17:55:51Z
dc.date.available2007-03-23T17:55:51Z
dc.date.issued2005
dc.degree.disciplineNeuroscience
dc.degree.fieldArts and Science
dc.degree.grantorUniversity of Lethbridge
dc.degree.levelDoctoral (Ph.D)
dc.degree.levelPH.D, Neuroscience
dc.degree.levelPhD
dc.degree.nameDoctor of Philosophy (Neuroscience)
dc.degree.subfieldSciences
dc.descriptioniii, 236 leaves : ill. (some col.) ; 29 cm.en
dc.description.abstractThe purpose of the current thesis was twofold: (1) to examine various factors that might be contributing to age-related learning and memory deficits specifically related to the hippocampus, and (2) to validate our rat model of aging, employing a multilevel analysis. We found age-related deficits on both spatial and non-spatial hippocampus-dependent taks that were accompanied by structural alterations observed in vivo (volune, but not neuronal metabolic function) and post mortem (neuronal density and neurogenesis, but not synaptic or mitochondrial density). Furthermore, our results suggest that the observed hippocampal structural changes, named decreased volume and neurogenesis, predict learning and memory deficits, and both can be accounted for by neurogenic reduction. In addition, the above-mentioned pattern of age-related deficits closely resembles that seen in humans, suggesting the present rat version of aging to be a very useful model for investigating hippocampal aging in humans.en
dc.formatpdf
dc.identifier.urihttps://hdl.handle.net/10133/12
dc.language.isoen_USen
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2005en
dc.publisher.departmentNeuroscienceen
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectBrain -- Aging -- Researchen
dc.subjectMemory -- Researchen
dc.subjectHippocampus (Brain) -- Physiology -- Researchen
dc.subjectRats as laboratory animalsen
dc.titleThe aging hippocampus : a multilevel analysis in the raten
dc.typeThesisen
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