The biomedical and bioengineering potential of protein nanocompartments

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dc.contributor.authorDemchuk, Aubrey M.
dc.contributor.authorPatel, Trushar R.
dc.date.accessioned2024-06-19T20:22:52Z
dc.date.available2024-06-19T20:22:52Z
dc.date.issued2020
dc.descriptionOpen access article. Creative Commons Attribution 4.0 International license (CC BY 4.0) applies
dc.description.abstractProtein nanocompartments (PNCs) are self-assembling biological nanocages that can be harnessed as platforms for a wide range of nanobiotechnology applications. The most widely studied examples of PNCs include virus-like particles, bacterial microcompartments, encapsulin nanocompartments, enzyme-derived nanocages (such as lumazine synthase and the E2 component of the pyruvate dehydrogenase complex), ferritins and ferritin homologues, small heat shock proteins, and vault ribonucleoproteins. Structural PNC shell proteins are stable, biocompatible, and tolerant of both interior and exterior chemical or genetic functionalization for use as vaccines, therapeutic delivery vehicles, medical imaging aids, bioreactors, biological control agents, emulsion stabilizers, or scaffolds for biomimetic materials synthesis. This review provides an overview of the recent biomedical and bioengineering advances achieved with PNCs with a particular focus on recombinant PNC derivatives.
dc.identifier.citationDemchuk, A. M., & Patel, T. R. (2020). The biomedical and bioengineering potential of protein nanocompartments. Biotechnology Advances, 41, Article 107547. https://doi.org/10.1016/j.biotechadv.2020.107547
dc.identifier.urihttps://hdl.handle.net/10133/6789
dc.language.isoen
dc.publisherElsevier
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.departmentDepartment of Chemistry and Biochemistry
dc.publisher.facultyArts and Science
dc.publisher.institutionUniversity of Lethbridge
dc.publisher.institutionUniversity of Calgary
dc.publisher.institutionUniversity of Alberta
dc.subjectNanoparticle
dc.subjectNanocage
dc.subjectVirus-like particle
dc.subjectBacterial microcompartment
dc.subjectEncapsulin
dc.subjectLumazine synthase
dc.subjectFerritin
dc.subjectSmall heat shock protein
dc.subjectVault
dc.subject.lcshNanoparticles
dc.titleThe biomedical and bioengineering potential of protein nanocompartments
dc.typeArticle
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