Sex differences for object location memory in rats : the contribution of the dentate gyrus

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dc.contributor.authorEhresman, Crystal
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSaucier, Deborah
dc.date.accessioned2011-07-11T18:07:08Z
dc.date.available2011-07-11T18:07:08Z
dc.date.issued2010
dc.degree.levelMasters
dc.descriptionix, 72 leaves : ill. ; 29 cmen_US
dc.description.abstractFemales exhibit superior object location memory (OLM) compared to males, but the reasons for this sex difference remains unknown. This thesis investigates the role of the dentate gyrus (DG) in an OLM task in normal rats (Experiment 1) and after bilateral adrenalectomy (ADX; Experiment 2). ADX is known to reduce volume of the DG and impair spatial learning. There was no sex difference for OLM in Experiment 1 but females exhibited superior OLM in Experiment 2. Experiment 2 found a significantly smaller DG due to ADX but this had no effect on behaviour. The male DG was significantly larger than the female DG in both experiments. Behaviour during the OLM task was not a predictor of DG volume, although a larger than average DG was related to poor OLM memory in females Thus, the DG involvement for OLM appears to differ between the sexes.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2476
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2010en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectMemoryen_US
dc.subjectDentate Gyrus -- Sex differencesen_US
dc.subjectMemory -- Testingen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectDissertations, Academicen_US
dc.titleSex differences for object location memory in rats : the contribution of the dentate gyrusen_US
dc.typeThesisen_US
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