Multiple-object memory requires the hippocampus

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dc.contributor.authorYim, Tonia Tan-Ling
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorWhishaw, Ian Q.
dc.date.accessioned2008-09-26T14:58:44Z
dc.date.available2008-09-26T14:58:44Z
dc.date.issued2007
dc.degree.levelMasters
dc.descriptionvii, 150 leaves : ill. ; 29 cm. --en
dc.description.abstractThis thesis investigates the role of the hippocampus in object memory. Currently, the role of the hippocampus in object recognition is unclear, with some studies demonstrating a delay-dependent impairment after hippocampal damage, others showing no impairment. The present thesis used the novel object recognition task and its variants to investigate various types of object memory in hippocampal lesion rats. In the first study, impairments were observed in discriminating object order and associating objects with contexts, while no impairment was observed in novel object recognition. In the second study, it was found that encountering another object shortly prior to or after encountering a target object impairs the recognition of the target object. In a control procedure, encountering a novel context either shortly before or after encountering the target object did not impair object recognition. In sum, in the absence of the hippocampus, object memory becomes vulnerable to interference, rendering rats unable to discern memories of multiple objects. The present thesis concludes that the hippocampus discriminates multiple objects via pattern separation. A stimulus-response model relating the role of the hippocampus to object memory is proposed.en
dc.identifier.urihttps://hdl.handle.net/10133/678
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2007en
dc.publisher.departmentDepartment of Neuroscienceen
dc.publisher.facultyArts and Scienceen
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectBrain -- Researchen
dc.subjectMemory -- Researchen
dc.subjectHippocampus (Brain) -- Physiology -- Researchen
dc.subjectRats as laboratory animalsen
dc.titleMultiple-object memory requires the hippocampusen
dc.typeThesisen
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