The effect of cannabinoids and anti-aging compounds on skin aging and rejuvenation

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dc.contributor.authorGerasymchuk, Marta
dc.contributor.supervisorKovalchuk, Igor
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2022-05-27T17:01:50Z
dc.date.available2022-05-27T17:01:50Z
dc.date.issued2022
dc.degree.levelPh.Den_US
dc.description.abstractCannabis sativa/indica has been used for medicinal and recreational purposes for over millennia. There are several approved medical indications for cannabis use in dermatological practice, including eczema, psoriasis, and severe pain. At the same time, there is a lack of scientific information about the anti-aging and rejuvenation properties of cannabinoids. We hypothesized that phytocannabinoids, cannabidiol (CBD) and tetrahydrocannabinol (THC), and nutrient signaling regulators (NSR), metformin, rapamycin, and triacetylresveratrol (TRSV), exert anti-aging and rejuvenating activity on skin fibroblasts. Results demonstrate that low doses of THC and CBD alone or combined with NSR lowered expression of senescence markers, stimulated ameliorative metabolic and functional activity, inhibited dermal aging processes, and positively affected the viability of skin fibroblasts. We found that TRSV alone or combined with THC/CBD might be a potential tool for enhancing regeneration and repair in injured tissues. The effectiveness of metformin or rapamycin alone or combined with phytocannabinoids was less effective.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6212
dc.language.isoen_USen_US
dc.proquest.subject0379en_US
dc.proquest.subject0369en_US
dc.proquest.subject0307en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciencesen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectAgingen_US
dc.subjectSkinen_US
dc.subjectCannabinoidsen_US
dc.subjectAnti-aging compoundsen_US
dc.subjectSIPSen_US
dc.subjectCellular senescenceen_US
dc.subject.lcshSkin--Aging
dc.subject.lcshSkin--Regeneration
dc.subject.lcshFibroblasts
dc.subject.lcshCannabinoids--Therapeutic use
dc.subject.lcshCannabis--Therapeutic use
dc.subject.lcshAging--Prevention
dc.subject.lcshDissertations, Academic
dc.titleThe effect of cannabinoids and anti-aging compounds on skin aging and rejuvenationen_US
dc.typeThesisen_US
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