An analysis of poststroke motor dysfunction and cerebral reorganization in rats

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dc.contributor.authorGonzalez, Claudia L. R.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKolb, Bryan
dc.date.accessioned2007-03-23T20:55:32Z
dc.date.available2007-03-23T20:55:32Z
dc.date.issued2004
dc.degree.disciplinePsychology and Neuroscience
dc.degree.fieldArts and Science
dc.degree.levelDoctor of Philosophy
dc.degree.levelPhD
dc.degree.subfieldScience
dc.descriptionxviii, 299 leaves : ill. (some col.) ; 29 cm.en
dc.description.abstractThis thesis investigates the behavioural and anatomical correlates of recovery from motor cortex damage in rats. The effectiveness of behavioural, pharmacological, and regenerative treatments was investigated using models of focal stroke. Chronic bilateral motor deficits were found after motor cortex damage induced by various methods. These behavioural deficits were similar in severity and duration although they were correlated with different patterns of reorganization seen in Golgi-stained tissue. Animals with motor cortex injury benefited from postinjury olfactory stimulation, chronic administration of nicotine, and infusions of epidermal growth factor followed by erythroprotein. Different mechanisms of plasticity in remaining cortical circuits are discussed as possible candidates responsible for the behavioural improvement. The current thesis expands the current knowledge of the effects of adult cortical damage to ares critical to motor control. It may also stimulate research on therapies and possible mechanisms that might enhance recovery after stroke.en
dc.identifier.urihttps://hdl.handle.net/10133/15
dc.language.isoen_USen
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2004en
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectCerebrovascular disease -- Animal modelsen
dc.subjectCerebrovascular disease -- Researchen
dc.subjectMotor ability -- Researchen
dc.subjectRats as laboratory animalsen
dc.titleAn analysis of poststroke motor dysfunction and cerebral reorganization in ratsen
dc.typeThesisen
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