Effects of cue type and overlap in context conditioning : the role of the hippocampus

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dc.contributor.authorBalog, Robert J.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcDonald, Robert J.
dc.date.accessioned2017-02-23T21:19:44Z
dc.date.available2017-02-23T21:19:44Z
dc.date.issued2016
dc.degree.levelMastersen_US
dc.description.abstractAn environmental context can be represented as a collection of individual features, or as a conjunction of elements combined by relational associations formed within the hippocampus. Separating out different experiences and then retrieving the correct representation becomes more challenging when cue elements start to overlap or become degraded. I designed a series of highly ambiguous context discrimination tasks based on sensory features including olfaction, vision, and geometric shape. Normal rats were able to discriminate highly ambiguous contexts defined by olfactory cues, visual cues, and certain geometric shapes. Rats with hippocampal lesions were impaired in the olfactory and visual task, and showed enhanced performance on the geometric shape task. In a final experiment, I demonstrated that rats learned a novel pattern separation/completion task that utilized olfactory information as the retrieval cue. These studies suggest that in context discriminations, some features are more important than others and this influences hippocampal involvement.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/4783
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquest.subject0384en_US
dc.proquest.subject0623en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectneuroscienceen_US
dc.subjecthippocampusen_US
dc.subjectcontext discriminationen_US
dc.subjectpattern completionen_US
dc.titleEffects of cue type and overlap in context conditioning : the role of the hippocampusen_US
dc.typeThesisen_US
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