Biodefense implications of new-world hantaviruses

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dc.contributor.authorD'Souza, Michael H.
dc.contributor.authorPatel, Trushar R.
dc.date.accessioned2023-02-08T22:00:46Z
dc.date.available2023-02-08T22:00:46Z
dc.date.issued2020
dc.descriptionOpen access article. Creative Commons Attribution 4.0 International License (CC BY 4.0) appliesen_US
dc.description.abstractHantaviruses, part of the Bunyaviridae family, are a genus of negative-sense, single-stranded RNA viruses that cause two major diseases: New-World Hantavirus Cardiopulmonary Syndrome and Old-World Hemorrhagic Fever with Renal Syndrome. Hantaviruses generally are found worldwide with each disease corresponding to their respective hemispheres. New-World Hantaviruses spread by specific rodent-host reservoirs and are categorized as emerging viruses that pose a threat to global health and security due to their high mortality rate and ease of transmission. Incidentally, reports of Hantavirus categorization as a bioweapon are often contradicted as both US National Institute of Allergy and Infectious Diseases and the Centers for Disease Control and Prevention refer to them as Category A and C bioagents respectively, each retaining qualitative levels of importance and severity. Concerns of Hantavirus being engineered into a novel bioagent has been thwarted by Hantaviruses being difficult to culture, isolate, and purify limiting its ability to be weaponized. However, the natural properties of Hantaviruses pose a threat that can be exploited by conventional and unconventional forces. This review seeks to clarify the categorization of Hantaviruses as a bioweapon, whilst defining the practicality of employing New-World Hantaviruses and their effect on armies, infrastructure, and civilian targets.en_US
dc.identifier.citationD'Souza, M. H., & Patel, T. R. (2020). Biodefense implications of new-world hantaviruses. Frontiers in Bioengineering and Biotechnology, 8, 925, https://doi.org/10.3389/fbioe.2020.00925en_US
dc.identifier.urihttps://hdl.handle.net/10133/6429
dc.language.isoen_CAen_US
dc.publisherFrontiers Mediaen_US
dc.publisher.departmentDepartment of Chemistry and Biochemistry
dc.publisher.facultyArts and Science
dc.publisher.institutionUniversity of Lethbridge
dc.publisher.institutionUniversity of Calgary
dc.publisher.institutionUniversity of Alberta
dc.publisher.urlhttps://doi.org/10.3389/fbioe.2020.00925
dc.subjectHantavirusen_US
dc.subjectSin Nombre Virusen_US
dc.subjectAndes Virusen_US
dc.subjectBiodefenseen_US
dc.subjectViral pandemicen_US
dc.subjectHantavirus cardiopulmonary syndromeen_US
dc.subjectTransmissionen_US
dc.subject.lcshHantavirus--Infections
dc.subject.lcshHantavirus pulmonary syndrome
dc.subject.lcshHantaviruses
dc.subject.lcshBioterrorism
dc.titleBiodefense implications of new-world hantavirusesen_US
dc.typeArticleen_US
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