dc.contributor.author	Deibel, Scott
dc.contributor.supervisor	McDonald, Robert J.
dc.date.accessioned	2018-01-22T17:32:23Z
dc.date.available	2018-01-22T17:32:23Z
dc.date.issued	2017
dc.degree.level	Ph.D	en_US
dc.description.abstract	With circadian rhythm disruption being a huge component of modern life, it is paramount to understand how it affects the brain and body. Circadian rhythm disruption impairs memory in humans and rodents. We use phase advances of the light dark cycle to challenge circadian rhythms in rats and observe concomitant memory impairments. While this has been extensively documented, it is unclear exactly how it occurs. The goals of this thesis were threefold: 1) Determine if our phase-shifting paradigm induces circadian misalignment. 2) Determine if the effects of our paradigm are long lasting. 3) Investigate three of the most theorized mechanisms for how circadian rhythm disruption elicits memory impairments. I found that our paradigm induces circadian misalignment that has long lasting effects on activity rhythms and memory. I also determined that sleep deprivation, elevated corticosterone, and hippocampal cell death are not responsible for the memory impairment induced by circadian rhythm disruption.	en_US
dc.description.sponsorship	NSERC; NSERC Create BIP	en_US
dc.embargo	No	en_US
dc.identifier.uri	https://hdl.handle.net/10133/5005
dc.language.iso	en_US	en_US
dc.proquest.subject	0317	en_US
dc.proquest.subject	0384	en_US
dc.proquestyes	Yes	en_US
dc.publisher	Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience	en_US
dc.publisher.department	Neuroscience	en_US
dc.publisher.faculty	Arts and Science	en_US
dc.relation.ispartofseries	Thesis (University of Lethbridge. Faculty of Arts and Science)	en_US
dc.subject	Circadian rhythms	en_US
dc.title	Circadian misalignment has harmful effects on the brain behaviour	en_US
dc.type	Thesis	en_US

Circadian misalignment has harmful effects on the brain behaviour

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