Cellular roles of the human Obg-like ATPase 1 (hOLA1) and its YchF homologs

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dc.contributor.authorBalasingam, Nirujah
dc.contributor.authorBrandon, Harland E.
dc.contributor.authorRoss, Joseph A.
dc.contributor.authorWieden, Hans-Joachim
dc.contributor.authorThakor, Nehal
dc.date.accessioned2020-10-28T18:58:45Z
dc.date.available2020-10-28T18:58:45Z
dc.date.issued2020
dc.descriptionPermission to archive accepted author manuscript.en_US
dc.description.abstractP-loop NTPases comprise one of the major superfamilies of nucleotide binding proteins, which mediate a variety of cellular processes, such as mRNA translation, signal transduction, cell motility, and growth regulation. In this review, we discuss the structure and function of two members of the ancient Obg-related family of P-loop GTPases: human Obg-like ATPase 1 (hOLA1), and its bacterial/plant homolog, YchF. After a brief discussion of nucleotide binding proteins in general and the classification of the Obg-related family in particular, we discuss the sequence and structural features of YchF and hOLA1. We then explore the various functional roles of hOLA1 in mammalian cells during stress response and cancer progression, and of YchF in bacterial cells. Finally, we directly compare and contrast the structure and function of hOLA1 with YchF before summarizing the future perspectives of hOLA1 research. This review is timely, given the variety of recent studies aimed at understanding the roles of hOLA1 and YchF in such critical processes as cellular-stress response, oncogenesis, and protein synthesis.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationBalasingam, N., Brandon, H. E., Ross, J. A., Wieden, H.-J., & Thakor, N. (2020). Cellular roles of human Obg-like ATPase 1 (hOLA1) and its YchF homologs. Biochemistry and Cell Biology, 98(1), 1-11. doi: 10.1139/bcb-2018-0353en_US
dc.identifier.urihttps://hdl.handle.net/10133/5797
dc.language.isoen_USen_US
dc.publisherCanadian Science Publishingen_US
dc.publisher.departmentAlberta RNA Research and Training (ARRTI)en_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.urlhttps://doi.org/10.1139/bcb-2018-0353en_US
dc.subjecthOLA1en_US
dc.subjectYchFen_US
dc.subjectCellular stressen_US
dc.subjectCancer progressionen_US
dc.subjectStructure-functionen_US
dc.titleCellular roles of the human Obg-like ATPase 1 (hOLA1) and its YchF homologsen_US
dc.typeArticleen_US
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Thakor, Nehalkumar
Wieden, Hans-Joachim