The role of cholinergic and serotonergic neocortical projections in controlling skilled movement in rats : evaluation of a model of dementia

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dc.contributor.authorGharbawie, Omar A.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorWhishaw, Ian Q.
dc.date.accessioned2007-04-30T21:18:33Z
dc.date.available2007-04-30T21:18:33Z
dc.date.issued2002
dc.degree.levelMasters
dc.descriptionvii, 166 leaves : ill. ; 28 cm.en
dc.description.abstractThe ascending cholinergic and serotonergic projections are central to cortical activation and normal behavior. The objective of this thesis was to determine whether unilaterally damaging both of these systems would disrupt the production of skilled movements on the contralateral side of the body. Rats received unilateral damage to either the ascending cholinergic, or serotonergic, or both projections. The respective lesions reduced neocortical leveles of acetylcholine and serotonin as assessed by acetylcholinesterase reactivity and immunohistochemical staining for serotonin. Subjects were assessed on a battery of sensorimotor tasks sensitive to neocortical integrity. The cholinergic lesion produced mild deficits on some taks but damage to both together did not abolish skilled movement. The impairments are decreased in relation to the severe effects of bilateral lesions. The results show that the sensorimotor cortex remains functional following deafferentation of both cholinergic and serotonergic afferents.en
dc.identifier.urihttps://hdl.handle.net/10133/177
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2002en
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDementia -- Researchen
dc.subjectRats -- Behavioren
dc.subjectCholinergic mechanisms -- Researchen
dc.subjectSerotoninergic mechanisms -- Researchen
dc.subjectDissertations, Academicen
dc.titleThe role of cholinergic and serotonergic neocortical projections in controlling skilled movement in rats : evaluation of a model of dementiaen
dc.typeThesisen
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