Effects of thyroid hormones, thyroid hormone disruptors, and treated wastewater on bullfrog tadpole chemosensory function and behaviour

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dc.contributor.authorHeerema, Jody L.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorPyle, Gregory
dc.date.accessioned2017-03-10T20:56:35Z
dc.date.available2017-03-10T20:56:35Z
dc.date.issued2017
dc.degree.levelMastersen_US
dc.description.abstractEndocrine disrupting compounds (EDCs) are persistent in wastewater effluent and discharged into receiving waters. Some EDCs can interact with the thyroid system in vertebrates. The present study investigated the effects of TH disruption on olfactory responses in Lithobates (Rana) catesbeiana tadpoles. A neurophysiological and a behavioural technique were developed to study olfactory acuity in tadpoles. To investigate the effects of thyroid hormone (TH) disruption, tadpoles were exposed to either 3,5’,3-triiodothyronine (T3), thyroxine (T4), 17β-estradiol (E2), known EDCs, or wastewater effluent. Olfactory-mediated avoidance responses to a chemosensory stimulus were measured. Exposure to T3 and treated wastewater resulted in impaired avoidance responses. Exposures to T4, E2 and known EDCs had no effect on behavioural responses. These results indicated that EDCs in wastewater effluent may contribute to olfactory impairment through TH disruption. Chemosensory-mediated behaviour may serve as an environmentally relevant endpoint to determine possible effects of TH disruption in wastewater effluent receiving waters.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/4793
dc.language.isoen_USen_US
dc.proquest.subject0306en_US
dc.proquest.subject0409en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta : University of Lethbridge, Dept. of Biological Sciencesen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectchemosensory-mediated behaviouren_US
dc.subjectendocrine disrupting compoundsen_US
dc.subjectolfactory acuityen_US
dc.subjectpremetamorphic tadpolesen_US
dc.subjectthyroid hormone disruptionen_US
dc.subjectwastewater effluenten_US
dc.titleEffects of thyroid hormones, thyroid hormone disruptors, and treated wastewater on bullfrog tadpole chemosensory function and behaviouren_US
dc.typeThesisen_US
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