The encoding of utility and its modulation by psychostimulants in rat anterior cingulate cortex

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dc.contributor.authorHashemnia, Saeedeh
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorGruber, Aaron J.
dc.contributor.supervisorEuston, David R.
dc.date.accessioned2019-09-05T20:07:05Z
dc.date.available2019-09-05T20:07:05Z
dc.date.issued2019
dc.degree.levelPh.Den_US
dc.description.abstractThe Anterior Cingulate Cortex (ACC) encodes many decision variables, including effort and reward. This region contains dense dopamine innervations and communicates with several brain regions known to participate in motivation. Lesion of the rat ACC and administration of d-amphetamine (AMPH), which increases extracellular catecholamines, affect choice behaviours. Here, I first investigated neural encoding in rat ACC in a binary choice task with varying amounts of effort and reward. Second, I examined the effects of AMPH on the neural encoding of task-relevant information. In addition to path, effort, and reward, I found that ACC neurons encode the utility. AMPH appeared to significantly disturb this information by decreasing reward encoding and utility signaling. Moreover, low-dose AMPH decreases population state-space volume and variations in neural trajectories; whereas, higher concentrations increase both. Our results thus demonstrate that the ACC is involved in processing the value of the ongoing action and AMPH impairs this function.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5550
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquest.subject0347en_US
dc.proquest.subject0419en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : Universtiy of Lethbridge, Department of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectAnterior Cingulate Cortexen_US
dc.subjectDecision-makingen_US
dc.subjectAmphetamineen_US
dc.subjectEffort-reward utilityen_US
dc.subjectElectrophysiologyen_US
dc.subjectDissertations, Academicen_US
dc.titleThe encoding of utility and its modulation by psychostimulants in rat anterior cingulate cortexen_US
dc.typeThesisen_US
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