Non-targeted effects of ionizing radiation in vivo : epigenetic aspects / Yaroslav Ilinytskyy

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dc.contributor.authorIlnytskyy, Yaroslav
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2012-03-28T18:41:38Z
dc.date.available2012-03-28T18:41:38Z
dc.date.issued2010
dc.degree.disciplineBiological Sciences
dc.degree.fieldArts and Science
dc.degree.levelDoctor of Philosophy
dc.degree.levelPhD
dc.degree.subfieldSciences
dc.descriptionxi, 190 leaves ; 28 cmen_US
dc.description.abstractThe classical paradigm of radiation biology is based on the notion that ionizing particle has to traverse a nucleus of a living cell in order to damage genetic material either directly or via production of short living free radicals. After DNA damage is introduced it can be either safely repaired and the cell can continue divisions unaltered; or it can result in a failure to repair and cells death; or finally, upon misrepair, the cell would be carrying genetic alteration that could result in cancer or developmental abnormality. Therefore modern risk estimations are based on the notion that nucleus is the true target of radiation effects and those are essentially stochastic with linear dependence on the dose. During the last two decades or so, a different idea was developed based on the observation that irradiated cells can communicate radiation induced stress signals to their unaffected neighbors and themselves become reprogrammed to maintained abnormal radiation-induced phenotype across multiple cellular divisions. Even more astonishingly this phenotype maybe transmitted by irradiated germ cells to unexposed progeny. Here we suggest that these non-targeted effects are maintained by epigenetic mechanisms and examine epigenetic underpinnings of bystander and transgenerational effects in vivo.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2630
dc.language.isoen_USen_US
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biomolecular Sciences, [c2010]en_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectRadiobiologyen_US
dc.subjectRadiation -- Physiological effecten_US
dc.subjectDissertations, Academicen_US
dc.titleNon-targeted effects of ionizing radiation in vivo : epigenetic aspects / Yaroslav Ilinytskyyen_US
dc.typeThesisen_US
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