Role of non-coding RNAs in amyloid beta neuropathology and Alzheimer's disease

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dc.contributor.authorSaville, Luke E.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorZovoilis, Athanasios
dc.date.accessioned2023-07-25T19:01:15Z
dc.date.available2023-07-25T19:01:15Z
dc.date.issued2023
dc.degree.levelPh.D
dc.description.abstractAlzheimer’s disease has a complex etiology and pathology. At the forefront of the disease is the amyloid beta neuropathology where amyloid plaques accumulate as the disease progresses, amidst a state of molecular dysfunction. A relatively understudied component of the molecular pathogenesis underlying Alzheimer’s disease is the potential role of non-coding RNAs as well as their RNA modifications. Here, an integrative molecular and computational approach is used to study the role of non-coding RNAs in the APP NL-G-F Alzheimer’s disease mouse model and human Alzheimer’s disease patients, unveiling that non-coding RNAs transcribed from Short Interspersed Nuclear Elements (SINEs) in mice and humans are aberrantly processed in connection with alterations in gene expression. As well, adenosine to inosine RNA editing is shown to be dysregulated in SINE RNAs and non-coding RNAs involved in protein expression are differentially modified in the hippocampus of APP NL-G-F mice.
dc.identifier.urihttps://hdl.handle.net/10133/6544
dc.language.isoen
dc.proquest.subject0307
dc.proquest.subject0379
dc.proquest.subject0487
dc.proquestyesYes
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistry
dc.publisher.departmentDepartment of Chemistry and Biochemistry
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectnon-coding RNAs
dc.subjectamyloid beta neuropathology
dc.subjectAlzheimer's disease
dc.subjectgene expression alterations
dc.subject.lcshNon-coding RNA--Research
dc.subject.lcshAlzheimer's disease--Research
dc.subject.lcshAlzheimer's disease--Molecular aspects--Research
dc.subject.lcshNervous system--Diseases
dc.subject.lcshGene expression
dc.subject.lcshGenetic regulation
dc.subject.lcshAmyloid beta protein--Research
dc.subject.lcshDissertations, Academic
dc.titleRole of non-coding RNAs in amyloid beta neuropathology and Alzheimer's disease
dc.typeThesis
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