Experience dependent plasticity of stroke outcome

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dc.contributor.authorRakai, Brooke D.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorPrusky, Glen
dc.date.accessioned2011-08-19T19:22:04Z
dc.date.available2011-08-19T19:22:04Z
dc.date.issued2008
dc.degree.levelMasters
dc.descriptionvi, 135 p. : ill. ; 29 cmen_US
dc.description.abstractStroke outcome is highly variable. Experiments in this thesis test the hypothesis that experience prior to a stroke is an important variable in the manifestation of stroke. Optokinetic tracking was used to evaluate the effects of visual cortex stroke and MCA occlusion in rats. Normal laboratory rats showed a small, but significant decrease in tracking thresholds following visual cortex stroke. Animals with developmental visuomotor experience or reach training experience in adulthood, however, had tracking thresholds which were substantially increased, and the effects of visual cortex strokes were greater. MCA occlusions did not affect tracking behaviour. These data indicate that specific experiences engage neural plasticity that can alter brain function. These changes can, in turn, affect the behavioural manifestation of a stroke. Understanding the effect that environmental experience has on stroke outcome promises to enable better characterization of strokes, and set appropriate behavioural baselines for the measurement of recovery of function.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2518
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2008en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectCerebrovascular diseaseen_US
dc.subjectCerebrovascular disease -- Animal modelsen_US
dc.subjectCerebrovascular disease -- Researchen_US
dc.subjectNeuroplasticityen_US
dc.subjectNeuroplasticity -- Researchen_US
dc.subjectNeuroplasticity -- Animal modelsen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectDissertations, Academicen_US
dc.titleExperience dependent plasticity of stroke outcomeen_US
dc.typeThesisen_US
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