The role of the hippocampus and post-learning hippocampal activity in long-term consolidation of context memory

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dc.contributor.authorGulbrandsen-MacDonald, Tine L
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.
dc.date.accessioned2012-04-11T17:39:21Z
dc.date.available2012-04-11T17:39:21Z
dc.date.issued2011
dc.degree.levelMasters
dc.descriptionx, 85 leaves : ill. ; 29 cmen_US
dc.description.abstractSutherland, Sparks and Lehmann (2010) proposed a new theory of memory consolidation, termed Distributed Reinstatement Theory (DRT), where the hippocampus (HPC) is needed for initial encoding but some types of memories are established in non-HPC systems through post-learning HPC activity. An evaluation of the current methodology of temporary inactivation was conducted experimentally. By permanently implanting two bilateral guide cannulae in the HPC and infusing ropivacaine cellular activity could be reduced by 97%. Rats were trained in a context-fear paradigm. Six learning episodes distributed across three days made the memory resistant to HPC inactivation while three episodes did not. Blocking post-learning HPC activity following three of six training sessions failed to reduce the rat’s memory of the fearful context. These results fail to support DRT and indicate that one or more memory systems outside the HPC can acquire context memory without HPC post-event activity.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2635
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2011en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectHippocampus (Brain) -- Physiologyen_US
dc.subjectHippocampus (Brain) -- Researchen_US
dc.subjectMemory -- Researchen_US
dc.subjectMemory -- Physiological aspectsen_US
dc.subjectMemory disordersen_US
dc.subjectBrain -- Localization of functionsen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectDissertations, Academicen_US
dc.titleThe role of the hippocampus and post-learning hippocampal activity in long-term consolidation of context memoryen_US
dc.typeThesisen_US
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