Neural correlates of sensation and navigation in the retrosplenial cortex

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dc.contributor.authorMao, Dun
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2018-01-23T16:05:49Z
dc.date.available2018-01-23T16:05:49Z
dc.date.issued2017
dc.degree.levelPh.Den_US
dc.description.abstractBy virtue of its anatomical connections, the retrosplenial cortex (RSC) is well suited to mediate bidirectional communication between the hippocampal formation and the neocortex. However, what information is encoded in the firing of RSC neurons is largely unclear. I used 2-photon calcium imaging to measure RSC population activity during a goal-directed virtual spatial task that was sometimes complemented by drifting gratings visual stimuli. Over 10% of RSC neurons, mainly in superficial layers, showed place fields with properties similar to CA1 place cells measured in the same task. A distinct subset of neurons (~15%), predominantly in agranular RSC, showed pronounced responses to the visual stimuli. Some of these RSC visual neurons were specifically selective for the speed and direction of visual motion. The results suggest that RSC contains multiple functional cell types distributed differentially across depths and subregions showing responses to external sensory stimulation and internal navigational signals.en_US
dc.description.sponsorshipNERF AIHS NSERCen_US
dc.embargoYesen_US
dc.embargo.end2017-07-10
dc.embargo.start2017-01-10
dc.identifier.urihttps://hdl.handle.net/10133/5011
dc.language.isoenen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectHippocampus (Brain)en_US
dc.subjectRetrosplenial cortexen_US
dc.subjectSpatial navigationen_US
dc.titleNeural correlates of sensation and navigation in the retrosplenial cortexen_US
dc.typeThesisen_US
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