Quality not quantity: deficient juvenile play experiences lead to altered medial prefrontal cortex neurons and sociocognitive skill deficits

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dc.contributor.authorHam, Jackson R.
dc.contributor.authorSzabo, Madeline
dc.contributor.authorAnnor-Bediako, Jessica
dc.contributor.authorStark, Rachel A.
dc.contributor.authorIwaniuk, Andrew N.
dc.contributor.authorPellis, Sergio M.
dc.date.accessioned2024-08-29T21:00:59Z
dc.date.available2024-08-29T21:00:59Z
dc.date.issued2024
dc.descriptionOpen access article. Creative Commons Attribution-NonCommercial 4.0 International license (CC BY-NC 4.0) applies
dc.description.abstractReduced play experience over the juvenile period leads to adults with impoverished social skills and to anatomical and physiological aberrations of the neurons found in the medial prefrontal cortex (mPFC). Even rearing rats from high-playing strains with low-playing strains show these developmental consequences. In the present study, we evaluated whether low-playing rats benefit from being reared with higher playing peers. To test this, we reared male Fischer 344 rats (F344), typically thought to be a low-playing strain, with a Long–Evans (LE) peer, a relatively high-playing strain. As juveniles, F344 rats reared with LE rats experienced less play and lower quality play compared to those reared with another F344. As adults, the F344 rats reared with LE partners exhibited poorer social skills and the pyramidal neurons of their mPFC had larger dendritic arbors than F344 rats reared with same-strain peers. These findings show that being reared with a more playful partner does not improve developmental outcomes of F344 rats, rather the discordance in the play styles of F344 and LE rats leads to poorer outcomes.
dc.description.peer-reviewYes
dc.identifier.citationHam, J. R., Szabo, M., Annor-Bediako, J., Stark, R. A., Iwaniuk, A. N., & Pellis, S. M. (2024). Quality not quantity: Deficient juvenile play experiences lead to altered medial prefrontal cortex neurons and sociocognitive skill deficits. Developmental Psychobiology, 66(2), Article e22456. https://doi.org/10.1002/dev.22456
dc.identifier.urihttps://hdl.handle.net/10133/6898
dc.language.isoen
dc.publisherWiley
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyCanadian Centre for Behavioral Neuroscience
dc.publisher.institutionUniversity of Lethbridge
dc.publisher.urlhttps://doi.org/10.1002/dev.22456
dc.subjectCg3 pyramidal neurons
dc.subjectDevelopment
dc.subjectExcecutive function
dc.subjectPlasticity
dc.subjectPrelimbic cortex
dc.subjectRough-and-tumble play
dc.subjectPlayfulness
dc.subjectSocial skills
dc.subject.lcshPlay behavior in animals
dc.subject.lcshRats--Behavior
dc.titleQuality not quantity: deficient juvenile play experiences lead to altered medial prefrontal cortex neurons and sociocognitive skill deficits
dc.typeArticle
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