Chronic noise stress affects neocortical and hippocampal-amygdala functional connectivity in mice

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dc.contributor.authorSholomiski, Megan
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and science
dc.contributor.supervisorKolb, Bryan
dc.contributor.supervisorMohajerani, Majid H.
dc.date.accessioned2021-01-13T15:10:58Z
dc.date.available2021-01-13T15:10:58Z
dc.date.issued2020
dc.degree.levelMastersen_US
dc.description.abstractThis thesis examines the effects of chronic noise stress on neocortical and hippocampal-amygdala networks and their behavioural correlates. Psychological symptoms of stress, including anxiety and depression, are thought to be caused by alterations in functional connectivity within the brain. A functional pathway has been established between the basolateral amygdala, which mediates emotional responses to stressors, the ventral hippocampus which provides context to emotional memories and experiences, and medial prefrontal cortex, which alters attention and perception of stressors. This network is adaptive in the presence of an acute stressor, allowing an organism to optimally prepare and deal with the source of stress, but may become dysfunctional when exposed to chronic stress. The hypotheses that chronic noise stress correlates to neocortical hyperconnectivity and decreased synchrony between the amygdala and hippocampus, correlates to altered behaviour, and correlates to altered brain morphology were tested in head-fixed mice using optical imaging and behavioural recordings.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5820
dc.language.isoen_USen_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquest.subjectPublic health [0573]en_US
dc.proquest.subjectMental health [0347]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectDissertations, Academicen_US
dc.subjectStress (Psychology) -- Animal modelsen_US
dc.subjectAmygdaloid bodyen_US
dc.subjectAnxietyen_US
dc.subjectDepression, Mental -- Animal modelsen_US
dc.subjectHippocampus (Brain)en_US
dc.subjectNoise -- Health aspectsen_US
dc.titleChronic noise stress affects neocortical and hippocampal-amygdala functional connectivity in miceen_US
dc.typeThesisen_US
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