Neonatal stroke in rats impairs behaviour, anatomy, and neurophysiology in adulthood

Simple item page
dc.contributor.authorWilliams, Preston T.J.A.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKolb, Bryan
dc.date.accessioned2016-02-27T19:30:33Z
dc.date.available2016-02-27T19:30:33Z
dc.date.issued2009
dc.degree.levelPh.Den_US
dc.description.abstractIn Canada, every ten minutes someone will have a stroke injury to the brain. According to the Heart and Stroke Foundation of Canada 15% of the patients will die and only 10% of patients will recover normal behaviour completely. The remaining 75% of stroke patients will experience one or many cognitive and motor neurological deficits. This thesis examines a rat model of human perinatal stroke populations most at risk to study the long-term behavioural, neurophysiological, and anatomical outcomes in maturity. Evidence is provided showing that the nature of motor deficits is dependent on the age- of-stroke and earlier ages do not lead to better outcomes. These data are important because they show that motor learning requires an optimal organization of the motor cortex to support motor behaviours. Early experiences, such as a stroke, can impair motor skills and the organization and function of the motor system in adulthood.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/4434
dc.language.isoen_CAen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Department of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectperinatal strokeen_US
dc.subjectrat modelen_US
dc.subjectmotor-deficitsen_US
dc.subjectdrug treatment evaluationen_US
dc.subjectmotor mapsen_US
dc.subjectbehaviour-brain plasticityen_US
dc.subjectneonatal hypoxic ischemiaen_US
dc.titleNeonatal stroke in rats impairs behaviour, anatomy, and neurophysiology in adulthooden_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Williams_Preston_PhD_2009.pdf
Size:
6.95 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses