The impacts of a cannabis extract on brain pathology and memory impairments associated with Alzheimer's disease in an APP-NL-G-F transgenic mouse model

Simple item page
dc.contributor.authorRobinson, Danika Andrea
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMcDonald, Robert J.
dc.date.accessioned2024-01-25T16:43:17Z
dc.date.available2024-01-25T16:43:17Z
dc.date.issued2023
dc.degree.levelMasters
dc.description.abstractAlzheimer’s Disease (AD) is a devastating neurodegenerative disorder that is categorized by progressive memory loss and cognitive deterioration. Amyloid-beta (Aꞵ) proteins accumulate within AD brains and trigger harmful chronic inflammation. By targeting both Aꞵ and inflammation, disease progression may be delayed. Cannabis is a plant containing THC and CBD. Previous work in our lab has shown that these compounds are ineffective at reducing AD pathology independently; however, research suggests they are more effective when combined. This project utilizes a THC/CBD combination extract to evaluate AD pathology in APP mice by assessing performance on memory-based behavioural tasks and by using protein markers to determine disease progression and severity. There were no treatment-related effects of the extract found via behavioural testing. However, the extract did decrease PFC 4G8-stained Aꞵ plaques. There were no other significant effects on Aꞵ, inflammation, or HPC cell volume found. Sex differences were found on various behavioural tasks.
dc.identifier.urihttps://hdl.handle.net/10133/6670
dc.language.isoen
dc.proquest.subject0317
dc.proquest.subject0493
dc.proquestyesYes
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectAlzheimer's disease
dc.subjectcannabis extract
dc.subjectbrain pathology
dc.subjectmemory impairments
dc.subjectamyloid-beta proteins
dc.subjectchronic inflammation
dc.subjectTHC
dc.subjectCBD
dc.subject.lcshAlzheimer's disease--Research
dc.subject.lcshAlzheimer's disease--Alternative treatment--Research
dc.subject.lcshAlzheimer's disease--Animal models
dc.subject.lcshCannabis--Therapeutic use--Research
dc.subject.lcshTetrahydrocannibinol--Therapeutic use--Research
dc.subject.lcshAmyloid beta-protein--Research
dc.subject.lcshMice as laboratory animals
dc.subject.lcshTransgenic mice
dc.subject.lcshCannabinoids--Therapeutic use--Research
dc.subject.lcshPlant extracts--Therapeutic use--Research
dc.subject.lcshDissertations, Academic
dc.titleThe impacts of a cannabis extract on brain pathology and memory impairments associated with Alzheimer's disease in an APP-NL-G-F transgenic mouse model
dc.typeThesis
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ROBINSON_DANIKA_MSC_2023.pdf
Size:
2.3 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
3.25 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses