A mouse model for studying stroke induced impairments, recovery, and compensation in the motor cortex

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dc.contributor.authorFarr, Tracy Deanne
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorWhishaw, Ian Q.
dc.date.accessioned2007-04-25T19:38:05Z
dc.date.available2007-04-25T19:38:05Z
dc.date.issued2003
dc.degree.levelMasters
dc.descriptionviii, 115 leaves : ill. ; 29 cm.en
dc.description.abstractStroke is the third leading cause of death and survivors suffer motor impairments. The rodent sensorimotor system is similar to the human's, making rodents a good model to study the effects of stroke. Transgenic technology makes the mouse a desirable stroke model, however, there are few behavioural tests to assess behavioural outcome. This thesis evaluates mice subjected to permanent or temporary occlusion focal motor cortex strokes in a skilled reaching task. The first experiment documents changes in skilled movements in mice with a permanent occlusion focal motor cortex stroke. The second experiment is identical but uses a temporary occlusion focal motor cortex stroke. The third experiment compares the two strokes. The results indicate permanent occlusion mice suffer great impairments, and a larger injury, than temporarily occluded animals. The mice with the largest insults were most impaired. Mice make an excellent behavioural and genetic model for studying motor system stroke.en
dc.identifier.urihttps://hdl.handle.net/10133/156
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2003en
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectCerebrovascular disease -- Animal modelsen
dc.subjectCerebrovascular disease -- Complicationsen
dc.subjectCerebrovascular disease -- Research -- Methodologyen
dc.subjectDissertations, Academicen
dc.titleA mouse model for studying stroke induced impairments, recovery, and compensation in the motor cortexen
dc.typeThesisen
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