Radiation responses of chemoresistant adenocarcinoma cells : from molecular mechanisms to new reversal strategies

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dc.contributor.authorLuzhna, Lidiya
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2011-07-22T17:28:46Z
dc.date.available2011-07-22T17:28:46Z
dc.date.issued2009
dc.degree.levelMasters
dc.descriptionxi, 98 leaves : ill. (some col.) ; 29 cmen_US
dc.description.abstractBreast cancer is a major cause of cancer-related death among women throughout the world. Treatment of breast cancer often fails due to the development of resistance to both chemo- and radiotherapy. The aim of this study was to analyze and compare the response to radiation of MCF-7 breast adenocarcinoma cells and MCF-7 cells that are resistant to doxorubicin (MCF-7/DOX). The results presented in this thesis show that drug-resistant MCF-7/DOX cells survive high doses of radiation exposure better than MCF-7 cells. Moreover, the chemo- and radioresistance of MCF-7/DOX cells share common molecular mechanisms and loss of sensitivity to radiation in chemo-resistant cells may be explained by alterations in their DNA methylation profile. The results of experiments presented in this thesis may, therefore, serve as a first step for future analysis of tumour resistance to radio- and chemotherapy and for the development of novel epigenetic strategies for reversal of breast cancer resistance to cytotoxic treatment regimens.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2487
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2009en_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectBreast -- Canceren_US
dc.subjectAdenocarcinoma -- Researchen_US
dc.subjectDoxorubicinen_US
dc.subjectRadiotherapyen_US
dc.subjectDrug resistance in cancer cells -- Researchen_US
dc.subjectDissertations, Academicen_US
dc.titleRadiation responses of chemoresistant adenocarcinoma cells : from molecular mechanisms to new reversal strategiesen_US
dc.typeThesisen_US
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