Chronic Traffic Noise Exposure Contributes to Emergence of Cognitive and Motor Functions Impairment and Increases Amyloid-β Deposition in Mouse Model of Alzheimer’s Disease

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dc.contributor.authorKarem, Hadil
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMohajerani, Majid H.
dc.date.accessioned2019-06-19T20:07:33Z
dc.date.available2019-06-19T20:07:33Z
dc.date.issued2019
dc.degree.levelMastersen_US
dc.description.abstractTraffic noise has become a daily source of stress in the modern societies. living next to high traffic roads has shown to be associated with increased risk of developing dementia. We employed a combination of behavioral, biochemical, and histological techniques to investigate the impact of chronic traffic noise exposure on the development of the Alzheimer’s Disease. For that, 21 APPNL-G-F male and female mice (10 males and 11females) were randomly assigned to the traffic noise or control group. Animals were exposed to 8 hours/day of 75 dB for 30 days to model traffic noise, and the effect on corticosterone levels, animals’ behavior, and development amyloid-ß (Aβ) plaques were examined at 4 and 6months post-exposure. Noise-exposed animals displayed anxiety-like behavior impaired balance and motor coordination with reduced learning and memory and increased Aβ plaques. These results provide evidence that traffic noise can impact the brain and predispose mice AD development.en_US
dc.description.sponsorshipThe Libyan Ministry of Higher Educationen_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/5414
dc.language.isoen_USen_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquest.subjectBehavioral sciences [0602]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectAlzheimer's Diseaseen_US
dc.subjectAmyloid-ß plaquesen_US
dc.subjectCorticosteroneen_US
dc.subjectTraffic noiseen_US
dc.titleChronic Traffic Noise Exposure Contributes to Emergence of Cognitive and Motor Functions Impairment and Increases Amyloid-β Deposition in Mouse Model of Alzheimer’s Diseaseen_US
dc.typeThesisen_US
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