Molecular insights into the effects of cancer and chemotherapy on the brain

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dc.contributor.authorKovalchuk, Anna
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKolb, Bryan
dc.contributor.supervisorGibb, Robbin L.
dc.date.accessioned2017-11-28T16:35:18Z
dc.date.available2017-11-28T16:35:18Z
dc.date.issued2017
dc.degree.levelPh.Den_US
dc.description.abstractAn array of central nervous system complications, neurological deficits, and cognitive impairments come about and persist as a result of cancer and cancer treatments. These conditions are known as ‘tumor brain’ and ‘chemo brain’, respectively, and affect many cancer survivors. We proposed that the mechanisms behind tumor and chemo brain were epigenetic and associated with aberrant global gene expression and metabolome deregulation. We used mouse TumorGraft models of breast, lung, and pancreatic cancer, and sarcoma to profile the epigenetic, transcriptome, small RNAome, and metabolome changes in chemo-treated tumor-bearing mice, as compared to untreated tumor-bearing mice, and to control mice. We noted that tumor presence alone caused oxidative stress and affected global gene and small RNA expression, DNA methylation, and metabolic activity in the brain. Chemotherapy affected similar domains, at times seeming to build on tumor effects. The observed molecular changes strongly resembled those associated with neurodegenerative diseases and brain aging.en_US
dc.description.sponsorshipCanadian Institutes for Health Research Canada Vanier Graduate Scholarship Alberta Innovates - Health Solutions Graduate Scholarship University of Lethbridgeen_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/4987
dc.language.isoen_USen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : Universtiy of Lethbridge, Department of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectchemo brainen_US
dc.subjectchemotherapy side effectsen_US
dc.subjecttumor brainen_US
dc.subjectcentral nervous system toxicityen_US
dc.subjectCancer--Chemotherapy--Complicationsen_US
dc.subjectChemotherapy--Side effectsen_US
dc.subjectAntineoplastic agents--Side effectsen_US
dc.subjectCognition disordersen_US
dc.subjectNeurotoxic agentsen_US
dc.titleMolecular insights into the effects of cancer and chemotherapy on the brainen_US
dc.typeThesisen_US
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