Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

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dc.contributor.authorCraig, Laura
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMacDonald, Robert
dc.date.accessioned2015-06-10T20:12:09Z
dc.date.available2015-06-10T20:12:09Z
dc.date.issued2008
dc.degree.levelPh.Den_US
dc.degree.levelPhD
dc.description.abstractAlzheimer’s disease (AD) is the most common form of dementia affecting the elderly population today; however, there is currently no accurate description of the etiology of this devastating disorder. No single factor theory has been demonstrated as being causative; however, an alternative theory suggests that the interaction of multiple risk factors is responsible for AD. In this thesis I present data suggesting a neuroprotective role for acetylcholine during aging. Using a rat model of cholinergic depletion of the medial septum, I explored the effects of four common risk factors for AD (stress, seizures, stroke and circadian dysfunction) targeted at the hippocampus and examined the effects on measures of hippocampal dependent (water maze) and hippocampal independent (fear conditioning) memory. Here, I propose a role for acetylcholine- mediated compensatory mechanisms in the functional recovery observed following subthreshold insults similar to those commonly observed in the elderly.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/3693
dc.language.isoen_CAen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2008en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectAlzheimer's disease -- Researchen_US
dc.subjectAcetylcholine -- Researchen_US
dc.subjectBrain -- Agingen_US
dc.subjectCholinergic mechanismsen_US
dc.titleRevisiting the cholinergic hypothesis in the development of Alzheimer's diseaseen_US
dc.typeThesisen_US
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