Analysis of the interlink between glucose-6-phosphate dehydrogenase (G6PD) and lung cancer through multi-omics databases

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dc.contributor.authorThakor, Parth
dc.contributor.authorSiddiqui, M. Quadir
dc.contributor.authorPatel, Trushar R.
dc.date.accessioned2024-08-02T21:28:51Z
dc.date.available2024-08-02T21:28:51Z
dc.date.issued2024
dc.descriptionOpen access article. Creative Commons Attribution-NonCommercial 4.0 International license (CC BY-NC 4.0) applies
dc.description.abstractGlucose-6-Phosphate Dehydrogenase (G6PD) is a crucial enzyme that executes the pentose phosphate pathway. Due to its critical nodal position in the metabolic network, it is associated with different forms of cancer tumorigeneses and progression. Nonetheless, its functional role and molecular mechanism in lung cancer remain unknown. The present study provides intricate information associated with G6PD and Lung Cancer. Varieties of public datasets were retrieved by us, including UALCAN, TCGA, cBioPortal, and the UCSC Xena browser. The data obtained were used to assess the expression of G6PD, its clinical features, epigenetic regulation, relationship with tumour infiltration, tumour mutation burden, microsatellite instability, tumour microenvironment, immune checkpoint genes, genomic alteration, and patient's overall survival rate. The present study revealed that the G6PD expression was correlated with the clinical features of lung cancer including disease stage, race, sex, age, smoking habits, and lymph node metastasis. Moreover, the expression profile of G6PD also imparts epigenetic changes by modulating the DNA promoter methylation activity. Methylation of promoters changes the expression of various transcription factors, genes leading to an influence on the immune system. These events linked with G6PD-related mutational gene alterations (FAM3A, LAG3, p53, KRAS). The entire circumstance influences the patient's overall survival rate and poor prognosis. Functional investigation using STRING, GO, and KEGG found that G6PD primarily engages in hallmark functions (metabolism, immunological responses, proliferation, apoptosis, p53, HIF-1, FOXO, PI3K-AKT signaling). This work provides a wide knowledge of G6PD's function in lung cancer, as well as a theoretical foundation for possible prognostic therapeutic markers.
dc.identifier.citationThakor, P., Siddiqui, M. Q., & Patel, T. R. (2024). Analysis of the interlink between glucose-6-phosphate dehydrogenase (G6PD) and lung cancer throught multi-omics databases. Heliyon, 10(15), Article e35158. https://doi.org/10.1016/j.heliyon.2024.e35158
dc.identifier.urihttps://hdl.handle.net/10133/6836
dc.language.isoen
dc.publisherElsevier
dc.publisher.departmentDepartment of Chemistry and Biochemistry
dc.publisher.facultyArts and Science
dc.publisher.institutionCharotar University of Science and Technology
dc.publisher.institutionUniversity of Lethbridge
dc.publisher.institutionUniversity of Calgary
dc.publisher.institutionUniversity of Alberta
dc.subjectG6PD
dc.subjectLung cancer
dc.subjectTCGA
dc.subjectBiomarker
dc.subjectPrognosis
dc.subjectLUAD
dc.subjectLUSC
dc.subject.lcshLungs--Cancer
dc.subject.lcshGlucose-6-phosphate dehydrogenase
dc.subject.lcshCancer Genome Atlas (Program)
dc.subject.lcshCancer--Prognosis
dc.titleAnalysis of the interlink between glucose-6-phosphate dehydrogenase (G6PD) and lung cancer through multi-omics databases
dc.typeArticle
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