Behavioral endophenotypes of chronic unpredictable stress

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dc.contributor.authorBadenhorst, Cecilia
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorGruber, Aaron J.
dc.date.accessioned2019-02-08T19:01:19Z
dc.date.available2019-02-08T19:01:19Z
dc.date.issued2018
dc.degree.levelMastersen_US
dc.description.abstractStress is the response to a perceived or real threat. Acute incidences of stress can be beneficial. However, repeated stress can cause maladaptive changes in brain and behavior leading to neuropsychiatric illnesses. Among publications on chronic stress, only recently has its effects on decision-making been identified. I have designed a competitive choice task (CCT) to measure changes in decision-making. Decision-making behaviors in this task are governed by the dorsal lateral striatum, ventral striatum and medial prefrontal cortex. These behaviors that these structures mediate are lose-shift, win-stay, and extraneous feeder sampling, respectively. I find that chronic unpredictable stress increases win-stay behavior strategies, decreases extraneous feeder sampling and increases speed but does not affect lose-shift strategies. Chronic stress, therefore, increases activity within the ventral striatum and decreases activity within the medial prefrontal cortex.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/5290
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : Universtiy of Lethbridge, Department of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectBrain -- Effect of stress on -- Researchen_US
dc.subjectBrain -- Effect of stress on -- Animal modelsen_US
dc.subjectStress (Psychology) -- Researchen_US
dc.subjectStress (Psychology) -- Animal modelsen_US
dc.subjectAffective disorders -- Researchen_US
dc.subjectAffective disorders -- Animal modelsen_US
dc.subjectDecision makingen_US
dc.subjectAnimal models in researchen_US
dc.subjectDissertations, Academicen_US
dc.subjectchronic stressen_US
dc.subjectcompetitive choice tasken_US
dc.subjectmedial prefrontal cortexen_US
dc.subjectstress disordersen_US
dc.subjectventral striatumen_US
dc.titleBehavioral endophenotypes of chronic unpredictable stressen_US
dc.typeThesisen_US
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