Preconception paternal stress : impact on offspring epigenome, brain, and behavior throughout the lifespan

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dc.contributor.authorHarker, Allonna
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorGibb, Robbin L.
dc.contributor.supervisorKolb, Bryan
dc.date.accessioned2015-09-24T22:20:25Z
dc.date.available2015-09-24T22:20:25Z
dc.date.issued2015
dc.degree.levelMastersen_US
dc.description.abstractA rich literature has been amassed demonstrating the impact of early experience on the structure and function of the developing brain. Adverse maternal experience during the perinatal period has been implicated as a major risk factor for the development of psychopathologies later in life. Little information is available regarding the impact of experience during the preconception period. As spermatogenesis is a continuous process, experiences that have the ability to alter epigenetic regulation in fathers may actually change developmental trajectories of offspring. The aim of this thesis was to examine the lifelong impact of preconception paternal stress on the epigenome, brain morphology, and behavior of both male and female developing rat offspring. Profound and enduring changes in DNA methylation patterns, neuroanatomical measures, and behavioral outcomes of paternally stressed offspring were observed. Results from this study clearly demonstrate that preconception paternal stress during spermatogenesis can influence offspring epigenome, brain, and behavior.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/3747
dc.language.isoen_CAen_US
dc.proquest.subject0317en_US
dc.proquest.subject0758en_US
dc.proquest.subject0475en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectpaternalen_US
dc.subjectstressen_US
dc.subjectgolgien_US
dc.subjectdevelopmenten_US
dc.subjectbehavioren_US
dc.titlePreconception paternal stress : impact on offspring epigenome, brain, and behavior throughout the lifespanen_US
dc.typeThesisen_US
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