Factors influencing functional recovery following hemidecortication in rats

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dc.contributor.authorDay, Morgan M.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKolb, Bryan
dc.date.accessioned2007-05-13T20:30:38Z
dc.date.available2007-05-13T20:30:38Z
dc.date.issued2005
dc.degree.levelMasters
dc.descriptionx, 123 leaves ; 29 cm.en
dc.description.abstractLarge neocortical lesions, such as hemidecortication, are detrimental for motor and cognitive skills. This thesis investigates the effect of age at the time of lesion on functional outcome. Attempts were then made to improve the outcome by using two simple treatments, tactile stimulation and Fibroblast Growth Factor-2 (FGF-2). The functional outcome of animals was measured using a series of behavioural tests (Morris water task, skilled reaching, forelimb placing during spontaneous vertical exploration, and the sunflower seed task). A qualitative difference was noted between animals that received hemidecortication at post natal day ten (P 10) versus animals that received a hemidecortication in adulthood (postnatal day, P 90). When the tactile stimulation treatment was used on animals that received P 10 hemidecortication, cognitive and motor improvements were noted. The same was not true for injections of FGF-2. When given after P 10 hemidecortication, this treatment impaired the cognitive abilities of rats in the Morris water task. There are two main points from this project: 1) overall functional recovery is not better or worse but simply different based on the age at which the trauma occurred and 2) treatments have varied success with different types of brain injury.en
dc.identifier.urihttps://hdl.handle.net/10133/247
dc.language.isoen_USen
dc.publisherLethbridge, Alta. : University of Lethbridge, Facutly or Arts and Science, 2005en
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectBrain -- Wounds and injuries -- Researchen
dc.subjectRats as laboratory animalsen
dc.subjectBrain damage -- Researchen
dc.subjectCerebral cortex -- Wounds and inuries -- Researchen
dc.titleFactors influencing functional recovery following hemidecortication in ratsen
dc.typeThesisen
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